文献简介

出版社:Cardiovasc Intervent Radiol

作  者:Bruno Damascelli • Vladimira Ticha

编  号:10.1007/s00270-009-9786-1

关键字:Extramammary Paget’s disease  Intra-arterial chemotherapy  Liposomal doxorubicin  Paclitaxel-albumin nanoparticles

年  份:2011   点击量:834

文献摘要

Extramammary Paget’s disease (EMPD) is a rare intraepithelial neoplasm occurring less frequently in men and even more rarely in the axilla. A 59-year-old man with severe Parkinson’s disease presented with axillary EMPD. The neurological comorbidity made treatment of the EMPD problematical and prompted us to propose locoregional intra-arterial chemotherapy in single short sessions. Two innovative chemotherapeutic macrocomplexes were used: doxorubicin incorporated in large liposomes and the taxane paclitaxel incorporated in albumin nanoparticles.A therapeutic response was seen right from the first treatment and was macroscopically close to complete after four cycles. Five months after the end of treatment the patient had minimal visible disease and had enjoyed a distinct improvement in quality of life, with no noteworthy complications related to the intra-arterial chemotherapy with percutaneous transfemoral catheterization.

乳房外Paget(EMPD) 是一种罕见的上皮内肿瘤,在男性患者中发生的频率较低而且发生在腋下更为罕见。一名患有严重的帕金森病的59岁的男性患者表现出腋下EMPD症状。神经系统合并症对EMPD的治疗产生干扰,这促使我们提出在单一短期疗程内采用局部动脉灌注化疗法进行治疗。。采用两种创新型化学疗法的大型复合物:包含阿霉素的大型脂质体和紫杉烷紫杉醇结合的白蛋白纳米粒。在第一次治疗后就观察到了治疗反应,并且在四个疗程后,肉眼观察反应结束。治疗结束5个月后患者仅有轻微可见的病症,并且生活质量得到显著的改善,也没有显著的伴有经皮经股导尿与动脉灌注化疗相关的并发症。