文献简介

出版社:INDIAN JOURNAL OF MEDICAL SCIENCES

作  者:MOHAMMAD BAGHER OWLIA, GOLBARG MEHRPOOR

编  号:10.4103/0019-5359.53169

关键字:Adult-onset Still’s disease, adult Still’s disease, Still’s disease

年  份:2009   点击量:558

文献摘要

ABSTRACT

摘要

OBJECTIVE:

目的:

This article is an attempt to review recent literature regarding pathogenesis and clinical and laboratory findings in adult-onset Still.s disease (AOSD).

本文试图回顾有关成人Still’s病(AOSD)发病机理及临床和实验室检查结果的近期文献。

MATERIALS AND METHODS:

材料与方法:

A search was conducted in PubMed and Ovid for English language publications, using individual or linked search terms “adult-onset Still’s disease”, “adult Still’s disease”, “Still’s disease”, “AOSD”, and other related terms, from 1996 to 2009, and the clinically relevant articles were subsequently selected.

对于英语出版物,在PubMed和Ovid中用单个或链接搜索词“成人斯蒂尔病”、“成人Still病”、“Still病”、“AOSD”以及其他相关术语检索从1996年到2009年之间与临床相关的文章,随后选中。

RESULTS:

结果:

More than 1000 titles were reviewed by the authors, and the most important concepts were selected from 143 full-text articles.

作者回顾了超过1000种书刊,并从143篇全文文章中挑选出最重要的概念。

CONCLUSION:
结论:

Adult-onset Still.s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology and pathogenesis, usually presenting with high spiking fever accompanied by systemic manifestations. The disease is an entity with heterogeneous pathology; and diverse suggested etiologies, clinical manifestations and prognoses. There is no single diagnostic test for AOSD; rather, the diagnosis is based on a set of criteria, the most important of which are indeed clinical, but they also include paraclinical ones. Treatment aims at both minimizing inflammation and halting disease progression. For the former, nonsteroidal anti-inflammatory drugs have limited efficacy; so glucocorticoids in conjunction with disease-modifying antirheumatic drugs are also used. Novel therapeutic approaches such as anti-tumor necrosis factor blockade and monoclonal antibodies are promising.

成人Still’s病(AOSD)是一种病因和发病机制未知的罕见系统性炎症性疾病,通常它的出现伴有全身表现的高峰形热。本病是伴有多样化病理学的实体,并且多样化暗示着病因学、临床表现及预后。成人Still病没有单一的诊断测试,恰恰相反,诊断是依据一套标准,其中最重要的是真正的临床表现,但也包括临床奇异的一些特点。治疗目的在于尽量减少炎症并防止疾病恶化。对于前者,非甾体类抗炎药物疗效有限,因此通常将糖皮质激素与疾病修饰的抗风湿药物联合使用。新的治疗方法,如抗肿瘤坏死因子阻断和单克隆抗体是有希望的。