文献简介

出版社:Informa Healthcare

作  者:Der-Yuan Chen, Yi-Ming Chen, Hsin-Hua Chen, Chia-Wei Hsieh, Chi-Chen Lin, Joung-Liang Lan,

编  号:10.3109/03008200903461462

关键字:CD4+CD25high regulatory T cells; transforming growth factor-β; adult-onset Still’s disease; systemic lupus erythematosus; disease activity

年  份:2010   点击量:504

文献摘要

ABSTRACT
Objective
To determine circulating levels of CD4+CD25high regulatory T (Treg) cells and transforming growth 
factor-β (TGF-β) in patients with adult-onset Still’s disease (AOSD) and to examine the associations with disease activity and clinical course of this disease.
Methods
The frequencies of circulating CD4+CD25high Treg 
cells in 52 active AOSD patients, 42 active systemic lupus erythematosus (SLE) patients, and 22 healthy controls (HCs) were determined using flow cytometry analysis. Levels of serum TGF-β and soluble interleukin-2 receptor (sIL-2R) were measured by enzyme-linked immunosorbent assay.
Results
Significantly lower levels 
of circulating CD4+CD25high Treg cells and serum TGF-β were found in AOSD patients and SLE patients than those found in HCs. Levels of circulating CD4+CD25high Treg cells and TGF-β were inversely correlated with disease activity scores for AOSD patients and SLE patients. Circulating CD4+CD25high Treg cell frequencies were positively correlated with serum TGF-β levels for patients with both diseases. Levels of circulating CD4+CD25high Treg cells and TGF-β significantly increased, paralleling clinical remission and the decrease in levels of C-reactive protein and soluble interleukin-2 receptor after effective therapy in AOSD patients. AOSD patients with monocyclic course had significantly higher levels of circulating CD4+CD25high Treg cells and TGF-β compared to those with polycyclic and chronic articular course.
Conclusion 
Diminished levels of circulating 
CD4+CD25high Treg cells and TGF-β, and inverse correlation with disease activity in patients with AOSD and SLE might be involved in the pathogenesis of both diseases. Increased levels of circulating CD4+CD25high Treg cells or TGF-β might be associated with a favorable clinical course in AOSD patients.