文献简介

出版社:Experimental Hematology

作  者:Adam Jona, Peter Szodoray, and Arpad

编  号:

关键字:

年  份:2013   点击量:874

文献摘要


Abstract:

Hodgkin’s lymphoma is a lymphoid malignancy of the immune system. The pathognomonic Hodgkin and Reed-Sternberg cells (HRS) are derived mainly from monoclonal, preapoptotic B cells, and they carry rearranged, somatically mutated immunoglobulin heavy chains. In an appropriate microenvironment, HRS cells escape from apoptosis by several mechanisms, including single mutations, aberrant signaling pathways. Eventually, weakened immune surveillance leads to uncontrolled, disproportional B cell proliferation. This review summarizes the latest findings on the pathogenesis of Hodgkin lymphoma, with a special emphasis on immunologic processes, and depicts current and future immunotherapeutic regimens, which improve treatment outcomes and reduce late toxicities.

摘要:

霍奇金淋巴瘤是一种免疫系统的淋巴恶性肿瘤。霍奇金和里德-斯腾伯格细胞(HRS)的特异性病征主要来自单克隆的、前凋亡B细胞,以及他们的重排,体细胞突变的免疫球蛋白重链。在一个合适的微环境中,HRS细胞通过几种机制逃避凋亡,包括单基因突变和异常的信号通路。最终,削弱免疫监视导致不受控制、不成比例的B细胞增殖。本文综述了霍奇金淋巴瘤发病机制的最新研究成果,并且着重强调了其免疫过程,描绘了当前和未来的免疫治疗方案(包括提高治疗效果,减少后期毒性)。