文献简介

出版社:Leukemia & Lymphoma

作  者:Michael Shodell , Sanford Kempin and Frederick P. Siegal

编  号:10.3109/10428194.2014.893312

关键字:

年  份:2014   点击量:695

文献摘要


Abstract:
Hodgkin’s Disease (HD), usually a malignancy of early B-cells, is associated with an increased risk of opportunistic infections (OI). Previous studies of infectious complications of HD have documented skin anergy and a variety of in vitro defects associated with cell-mediated immunity. The spectrum of infections seen in HD resembles that seen in AIDS, where the setting for OI susceptibility has been better defined, in particular with respect to interferon-generation by plasmacytoid dendritic cells (pDCs). Longitudinal studies of patients with HIV infection indicated that development of simultaneous reductions in the ability of pDCs to produce interferon-alpha (IFN-), together with critically low numbers of circulating CD4+ T cells, was a prerequisite to OI development. This association was seen both during the natural history of human immunodeficiency-type 1 infection and during the period of immune reconstitution as effective antiretroviral infections became available. Subsequent studies by others have confirmed in HIV infection the importance of this dual pDC/CD4 defect in susceptibility to OI using IFN- generation and enumeration of pDC. Plasmacytoid DCs have been shown to be central to in vivo immune function and regulation.