文献简介

出版社:BioScience Trends

作  者:Makoto Goto, Yuichi Ishikawa, Masanobu Sugimoto, Yasuhiro Furuichi

编  号:10.5582/bst.2013.v7.1.13

关键字:Aging, cancer-prone syndrome, helicase, inflammation, longevity, premature aging, Werner syndrome

年  份:2013   点击量:722

文献摘要


Abstract:

 As ~75% of the Werner syndrome (WS) patients recognized between 1904 and 2008 all over the world are of Japanese origin, the most case reports and clinical studies on WS has been published in Japanese journals. Thus, the detailed English-written clinical review on the recent WS case reports has been warranted. Although WS has been characterized by a variety of clinical manifestations mimicking premature aging, the recent longevity and delayed age-associated manifestations observed both from Japanese WS and general population may suggest a common environmental effect on some gene(s) other than WRN and may give us a newer pathophysiological look at WS and also natural aging through the molecular dysfunction of WRN.

 摘要:

由于全世界范围内1904年至2008年之间确诊的Werner综合征(WS)患者大约有75%是源于日本的,因此大部分有关WS的病例报告和临床研究都是发表在日本的学术期刊上的。因此,有关近期WS病例报告的详细英文临床综述是很有必要的。尽管WS是以具有类似早衰的各种临床表现为特征,但最近在日本的WS患者和一般人群中均观察到寿命延长以及与延迟老化相关的临床表现,这可能暗示了是由于一个共同的环境对一些基因(S)的影响,而不是WRN,并且可能为我们提供了一个较新的病理生理学角度来看待WS以及通过WRN分子功能障碍实现的自然老化。