文献简介

出版社:Kluwer Academic/Plenum Publishers

作  者:Sezen, Okumus, Pehlivan, Dilli, Tarakcioğlu, Onat

编  号:10.1007/s10753-011-9328-2

关键字:Behcet’s disease; visfatin; TNF-α.

年  份:2012   点击量:1032

文献摘要

   The aim of our study is to determine the serum visfatin levels of patients with  Behcet's  disease and to investigate the relationship between visfatin, an adipokine released from adipose tissue, levels and activity of  Behcet's disease. Fifty-eight patients with Behcet's disease were enrolled to the study. Nineteen of the patients were inactive, and 39 of them were active. We enrolled 30 healthy subjects as being control group. Visfatin and tumor necrosis factor alpha (TNF-α) levels were measured with ELISA method. Visfatin levels were significantly lower in patients with Behcet's disease whose illnesses were active or inactive than the control group (p < 0.05). There was no significant difference between the active patient and inactive patient group. The reason for the lower levels of serum visfatin in active and inactive patients' group could be due to pro-inflammatory cytokines such as TNF-α and IL-6 which suppress genetic expression of visfatin in patients with Behcet's disease, or else
     本研究旨在确定白塞病患者的血清内脂素水平以及研究内脂素(一种由内脏组织释放的脂肪细胞因子)与白塞病的疾病水平及其活动性之间的关系。本研究纳入58位白塞病患者。其中19名患者没有疾病活动,另外39名患者表现有疾病活动。我们纳入30位健康人员作为对照组。应用ELISA法测量了内脂素以及肿瘤坏死因子α(TNF—α)水平。有疾病活动性或没有疾病活动性的白塞病患者的内脂素水平均明显低于对照组,有疾病活动性的患者组和没有疾病活动性的患者组之间没有明显差异。有和无疾病活动的患者组中较低的血清内脂素水平可能是由于促炎性细胞因子(诸如TNF-αIL-6)抑制白塞病患者内脂素的基因表达,或者是其他原因。