文献简介

出版社:Aves Yayincilik

作  者:Hasan Akkaya, Ömer Şahin1, Murat Borlu2, Abdurrahman Oğuzhan1, Mustafa Serkan Karakaş

编  号:10.5152/akd.2013.034

关键字:

年  份:2013   点击量:884

文献摘要

Objective:
    Behçet's disease (BD) is a systemic vasculitis, capable of involving all types of vessels. Endothelial dysfunction (ED) has been previously documented in BD. Previous studies showed that nebivolol might improve endothelial functions in endothelial dysfunction. The aim of our study is to assess the effects of nebivolol on endothelial dysfunction in patients with Behçet's disease.

 研究目的:
   白塞病(BD)是一种系统性血管炎,能累及所有类型的血管。白塞病中出现内皮功能障碍
(ED)先前已有记录。之前研究显示奈比洛尔可以改善内皮功能障碍的内皮功能。本研究旨在对奈比洛尔用于治疗白塞病患者的内皮功能障碍的疗效进行评定。
Methods:
    This study was designed as prospective single-arm controlled study. We prospectively studied 35 Behçet's patients who were diagnosed according to the International Study Group criteria. Patients received 5 mg nebivolol per day for 3 months. Endothelial dysfunction was evaluated by brachial artery flow-mediated dilatation (FMD) method using high-resolution vascular ultrasound device at baseline and after for 3-month therapy. The paired samples t test, Wilcoxon test, Pearson, Spearman correlation analyses were used for statistical analysis.
 研究方法:
     本研究设计为前瞻性单组对照试验。我们前瞻性地研究了35位白塞病患者(根据国际研究组织标准确诊)。受试患者三个月时间内每日服用奈比洛尔5mg。通过采用高分辨率血管超声设备的肱动脉血流介导性舒张法
(FMD)对治疗初始以及3个月后的内皮功能障碍进行评估。统计分析包括配对样本t检验、威尔科克森检验、以及皮尔森、斯皮尔曼相关性分析。

Results: 
    A significant improvement was observed in FMD after therapy period (4.23±1.19 vs 7.95±2.21%, p<0.001). The correlation analysis showed a negative correlation between post-treatment high-sensitive C-reactive protein and FMD (r=-0.435, p=0.009). No adverse effects were observed in treatment period.
研究结果:
    通过
FMD治疗周期结束后,疗效显著(4.23±1.19 vs 7.95±2.21%, p<0.001)相关性分析表明预后高敏C反应蛋白和FMD之间呈负相关(r=-0.435, p=0.009)。在治疗期间没有观察到药物对患者产生副作用。
Conclusion: 
    Nebivolol improved endothelial dysfunction in Behçet's patients. However, further comprehensive studies are needed to determine the long-term effects of nebivolol.
结论
    奈比洛尔改善了白塞病患者的内皮功能障碍状况。然而,还需要进一步综合性研究来确定奈比洛尔的长期疗效。


 





 

 


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