文献简介

出版社:Journal of Antimicrobial Chemotherapy

作  者:Noriyuki Nagano, Kouji Kimura, Yukiko Nagano, Hiroaki Yakumaru and Yoshichika Arakawa

编  号:10.1093/jac/dkp354

关键字:

年  份:2009   点击量:623

文献摘要

Abstract:
Penicillin is the first-line antibiotic for group B streptococci (GBS) in disease therapy as well as in intrapartum chemoprophylaxis because resistance to this agent has so far not been reported among GBS clinical isolates. However, we have recently reported GBS isolates with reduced penicillin susceptibility (PRGBS), where altered penicillin-binding protein (PBP) 2X demonstrates a major contribution to the reduction of b-lactam susceptibility.1 We have also shown a diversity of mutations in PBP genes among PRGBS, while those genes of the penicillin-susceptible strains were highly conserved, irrespective of their isolation dates.2 Those PRGBS isolates have been mostly recovered from respiratory specimens. Here, we report a case of a lasting sacral decubitus ulcer from which PRGBS were isolated repeatedly, together with the molecular characteristics of the isolates.