文献简介

出版社:JEADV

作  者:L. Wang, A.-E. Xu

编  号:10.1111/jdv.12264

关键字:clinical appearance, dermoscopy, confocal microscopy

年  份:2014   点击量:742

文献摘要

Background  Riehl’s melanosis often poses a diagnostic challenge because of the variability in clinical morphology. Reflectance confocal microscopy (RCM), similar to dermoscopy, images lesions in an en face plane, thus enabling direct correlations with dermoscopic images. No published data are currently available regarding dermoscopic and RCM findings in Riehl’s melanosis.
研究背景 由于Riehl黑变病临床形态学上具有可变性,因此,该病常难以诊断。反射共焦显微镜(RCM),其类似于皮肤镜,能够在表皮平面的病变成像,从而使之与皮肤镜图像一致。目前尚未公布有关Riehl黑变病的皮肤镜和RCM研究结果的可用数据。

Objectives  The aim of our study was to correlate the features of Riehl’s melanosis across various imaging modalities including dermoscopy, confocal microscopy and histopathological examination to give a more precise description of this disease to improve the accuracy of diagnosis.

研究目的 本研究旨在通过各种成像方式,找出Riehl黑变病特征的一致性,包括皮肤镜、激光共聚焦显微镜和组织病理学检查,从而更精准的描述该病,以提高诊断的准确性。

Methods  Fifteen patients with a previously established diagnosis of Riehl’s melanosis were recruited. All lesions were imaged using dermoscope and in vivo RCM, followed by complete excision for histopathological analysis.

研究方法 本研究招募了15例先前已确诊为Riehl黑变病的患者。首先,采用皮肤镜和体内RCM对所有病变成像,其次对完全切除的病变进行组织病理学分析。

Results   A series of dermoscopic and RCM features of Riehl’s melanosis were identified and shown to correlate well with histopathological examination. Pseudonetworks, grey dots/granules, liquefaction of basal cells, incontinence of pigment were the most distinctive characteristic.

研究结果  鉴定了Riehl黑变病一系列的皮肤镜和RCM特征,并显示其与组织病理学检查非常一致。 境界不清楚的网点状斑点/粒状斑点、基底细胞液化变性、色素失禁为其显著特征。

Conclusions  This study highlights the clinical, dermoscopic, confocal microscopic and histopathological features of Riehl’s melanosis. It is necessary to further define the diagnostic features of clinically difficult lesions with these modalities, but clinical evaluation should not be neglected.

研究结论 本研究强调Riehl黑变病的临床表现、皮肤镜、共聚焦显微镜和组织病理学特征。有必要使用这些成像方式,进一步确诊临床上难以识别的病变,但同时,不应忽略临床评估。