文献简介

出版社:Braz J Infect Dis

作  者:Andrade, Melo, Atta et al.

编  号:

关键字:hepatitis C,muscle, smooth, antibody specifi city, cryoglobulins, liver diseases.

年  份:2011   点击量:773

文献摘要

Cryoglobulinemia and non-organ-specific-autoantibody are biomarkers of autoimmunity of the chronic infection caused by hepatitis C virus (HCV). In this work, we report the association between the presence of smooth muscle antibodies (SMA) and cryoglobulinemia and chronic liver disease in HCV carriers. Sixty-five untreated HCV patients, 38 women and 27 men were included in this study. Cryoglobulinemia was tested by cryoprecipitation, SMA by indirect fluorescent antibody test, and liver fibrosis and hepatocellular inflammation activity was investigated by histology of liver biopsy using the METAVIR score. The prevalence of SMA in the patients was 33.8% and cryoglobulinemia was demonstrated in 36.9% patients. Cryoglobulinemia and SMA seropositivity was associated with advanced fibrosis (p < 0.05). The presence of SMA and cryoglobulinemia was not associated with hepatocellular inflammation activity, age, carrier gender or HCV genotype. We concluded that liver biopsy should be recommended for HCV carriers that are seropositive for SMA or cryoglobulinemia.

冷球蛋白血症和非器官特异性抗体是由丙型肝炎病毒(HCV)引发的慢性感染的自体免疫生物标志物。本文报道了在HCV携带者中抗平滑肌抗体(SMA)和冷球蛋白血症的存在与慢性肝病之间的关联。本研究纳入了65例未经治疗的HCV患者,其中38名女性和27名男性。通过冷冻沉淀对冷球蛋白血症进行检测,SMA通过间接荧光抗体检测, 应用METAVIR评分法,通过肝活检的组织学对肝纤维化和肝细胞炎症活性进行研究。 患者中SMA发病率为33.8%,冷球蛋白血症为36.9%。冷球蛋白血症和SMA血清反应呈阳性与晚期肝纤维化有关(P <0.05)。 SMA和冷球蛋白血症的存在与肝细胞炎症活性、年龄、携带者性别或HCV基因型无关。因此本文得出对SMA或冷球蛋白血症血清反应为阳性的HCV携带者建议进行肝组织活检。