文献简介

出版社:Clinical and Developmental Immunology

作  者:Giuseppe Sautto, NicasioMancini, Laura Solforosi, Roberta A. Diotti, Massimo Clementi, and Roberto Burioni

编  号:10.1155/2012/705013

关键字:IgV subfamilies,Type IIMixed Cryoglobulinemia

年  份:2012   点击量:429

文献摘要

The association between hepatitis C virus (HCV) infection and type II mixed cryoglobulinemia (MCII) is well established, but the role played by distinct HCV proteins and by specific components of the anti-HCV humoral immune response remains to be clearly defined. It is widely accepted that HCV drives the expansion of few B-cell clones expressing a restricted pool of selected immunoglobulin variable (IgV) gene subfamilies frequently endowed with rheumatoid factor (RF) activity. Moreover, the same IgV subfamilies are frequently observed in HCV-transformed malignant B-cell clones occasionally complicating MCII. In this paper, we analyze both the humoral and viral counterparts at the basis of cryoglobulins production in HCV-induced MCII, with particular attention reserved to the single IgV subfamilies most frequently involved.