文献简介

出版社:International Journal of STD & AIDS

作  者:MChrisofos MD, A Skolarikos MD, A Lazaris MD, S Bogris MD

编  号:

关键字:condyloma acuminatum, HPV, bladder, carcinogenesis

年  份:2004   点击量:965

文献摘要

Condyloma acuminatum is an anogenital lesion caused by human papillomavirus (HPV) infection, a common sexually transmitted disease. It usually affects the external genitalia while urethral and/or bladder involvement is rare. HPV types are classified into three categories depending on their oncogenic potential: low risk (type 6, 11, 42, 43, 44, 59, 66, 68, 70), intermediate risk (type 30, 31, 33, 34, 35, 39, 40, 49, 51, 52, 53, 57, 58, 63, 64) and high risk (type 16, 18, 45, 56). High-risk and intermediate-risk HPV-DNA types, together with other co-factors still to be defined, are responsible for over 90% of the cases of anogenital pre-malignant and malignant tumours. We report a unique case of a urinary bladder condyloma acuminatum positive for HPV 16/18 DNA, presented as the primary and only site of the disease in an immunocompetent patient. We review the treatment and follow-up strategies of this rare lesion.

  尖锐湿疣是一种由人类乳头瘤病毒(HPV)感染所致的肛门生殖器损害,是一种常见的性传播疾病。它通常影响外生殖器,很少累及尿道和/或膀胱部位。人类乳头瘤病毒依据其致癌潜力可分为三类:低风险(611、42434459666870)中风险(303133343539404951525357586364)和高风险(16184556)。高风险和中风险的HPV-DNA与其他辅助因子一起被认为是造成90%以上的肛门和生殖器癌前病变和恶性肿瘤的原因。我们报告了一例HPV16/18 DNA呈阳性的膀胱尖锐湿疣的特殊病例膀胱为该疾病在该患者(具有免疫能力)身上首要和唯一的位点。我们对这例罕见病变的治疗和随访策略进行了回顾。