文献简介

出版社:Canadian Journal Of Public Health

作  者:Gilbert M ; Li X ; Petric M ; Krajden M ; Isaac-Renton JL ; Ogilvie G ; Rekart ML

编  号:

关键字:Herpes simplex; herpes simplex, genital; epidemiology; Canada

年  份:2011   点击量:788

文献摘要

Objectives: Understanding the regional epidemiology of genital Herpes Simplex Virus (HSV) infections is important for clinical and public health practice, due to the increasing availability of type-specific serologic testing in Canada and the contribution of genital HSV-2 infection to ongoing HIV transmission. We used centralized laboratory data to describe trends in viral identifications of genital HSV in BC and assess the utility of these data for ongoing population surveillance.

研究目的:因为在加拿大特定类型的血清学检测日渐普及且生殖器疱疹病毒HSV-2感染导致了HIV持续传播,所以了解生殖器单纯疱疹病毒(HSV)感染的区域流行病学,对临床研究和公共卫生实践具有重要意义。我们利用中心实验室数据来描述BC生殖器疱疹病毒鉴定的发展趋势,并评估这些数据对于持续人口监测的效用。

Methods: Records of viral identifications (1997-2005) were extracted from the Provincial Public Health Microbiology & Reference Laboratory database. Classification as genital or other site was based on documented specimen site. We conducted a descriptive analysis of trends over time, and calculated odds of HSV-1 infection among individuals with genital herpes.

研究方法:我们对摘录自省公共卫生微生物学以及参考实验室数据库中(1997-2005年间)的病毒鉴定记录进行研究。生殖器疱疹或其他部位疱疹的分类都基于所记录的标本部位。随着时间的推移,我们对发展趋势进行了描述性分析,并计算出在生殖器疱疹个体中感染HSV-1的几率。

Results: Of 48,183 viral identifications, 56.8% were genital, 10.0% were peri-oral and 9.1% cutaneous; site was unknown for 22.9%. Among genital identifications, HSV-1 infection was more likely in females, younger age groups, and later time periods. The proportion of genital herpes due to HSV-1 increased over time from 31.4% to 42.8% in BC.

研究结果:在48,183例病毒鉴定中,56.8%感染部位在生殖器、10.0%在口周、9.1%在皮肤;其他未知部位占22.9%。在生殖器鉴定中,HSV-1感染更可能出现于女性,年轻群体以及随后周期。在BC省,随着时间的推移由于HSV-1感染所致的生殖器疱疹所占比例从31.4%上升至42.8% 

Conclusions: Our analysis of population-level laboratory data demonstrates that the proportion of genital herpes due to HSV-1 is increasing over time in BC, particularly among women and younger age groups; this has implications for clinical practice including the interpretation of type-specific serology. Provincial viral identification data are useful for monitoring the distribution of genital HSV-1 and HSV-2 infections over time. Improving clinical documentation of specimen site would improve the utility of these data.

研究结论:人口水平实验室数据的分析表明:在BC省,由于HSV-1感染所致生殖器疱疹比例随着时间的推移而增加,特别是在女性和年轻群体中;这对临床实践包括对特定类型的血清学阐释都产生影响。省病毒识别数据可有效监测(随着时间的推移)生殖器疱疹HSV-1HSV-2感染的分布情况。完善临床标本部位的)记录,可提高这些数据的有效性。

 

 

Mark Gilbert, MD et.al;Canadian Public Health Association, 2011;Vol.102(3);pp.225-29.