文献简介

出版社:The Cochrane Collaboration

作  者:R. J. Boyle, F. J. Bath-Hextall, J. Leonardi-Bee, D. F. Murrell and M. L-K Tang

编  号:10.1111/j.1365-2222.2009.03305.x

关键字:

年  份:2009   点击量:783

文献摘要

Background .

Probiotics have been proposed as a treatment for eczema, but the results of intervention trials have been mixed.

研究背景:

益生菌已被提议作为一种治疗湿疹的方法,但其干预试验的结果喜忧参半。

Objective .

To evaluate the efficacy of probiotics for treating eczema by performing a systematic review of randomized-controlled trials (RCTs).

研究目的:

本文旨在通过一项随机对照试验(RCTs)的系统性回顾,来评估应用益生菌治疗湿疹的有效性。

Design .

We searched the Cochrane Skin Group Specialised Register, Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PsycINFO, AMED, LILACS, ISI Web of Science, the reference lists of articles, ongoing clinical trial registers and conference proceedings. RCTs of live orally ingested microorganisms for the treatment of eczema were eligible for inclusion.

研究设计:

我们查阅了Cochrane Skin Group Specialised Register Cochrane临床试验对照数据库、MEDLINEEMBASEPsycINFOAMEDLILACSISI科学网,文章参考文献目录、正在进行的临床试验登记簿及会议论文。在随机对照试验(RCTs)中,入选了口服摄入活微生物治湿疹的方法。

Results .

Twelve trials (781 participants) were identified. Meta-analysis of data from five of these trials showed that there was no significant reduction in eczema symptoms with probiotic treatment compared with placebo (mean difference-0.90 points on a 20-point visual analogue scale; 95% confidence interval -2.84, 1.04). Meta-analysis of data from seven trials showed no significant difference in investigator rated eczema severity between probiotic and placebo treatments. Subgroup analysis by eczema severity or presence of atopy did not identify a specific population in which probiotic treatment was effective. There was significant heterogeneity between studies; however, the results of three studies that used the same probiotic strain were concordant. The adverse events search identified case reports of sepsis and bowel ischaemia caused by probiotics.

研究结果:

12项试验(781名参与者)进行鉴定。其中五项试验的数据经过荟萃分析表明,与安慰剂对照组相比益生菌疗法并没有显著减轻湿疹的症状(在20分的视觉模拟评分时平均差为0.90分;95%置信区间为-2.841.04)。其中七项试验的数据经过荟萃分析显示对于研究者评定湿疹严重程度益生菌疗法和安慰剂疗法没有显著的差异。根据湿疹严重程度或特应性反应的存在进行亚组分析,在益生菌疗法中没有鉴定出某种特殊群体对于治疗是有效的。研究之间存在着显著的异质性,然而,使用相同的益生菌菌株进行的三组试验的研究结果是一致的。不良反应在已确认的由益生菌引起败血症和肠道缺血的病例报告中发现。

Conclusions .

Currently, probiotics cannot be recommended for treating eczema. The heterogeneity between studies may be attributable to probiotic strain-specific effects, which means that novel probiotic strains may still have a role in eczema management.

研究结论:

目前,益生菌不能被推荐用于治疗湿疹。研究之间的异质性可能归因于益生菌菌株特异性影响,这意味着新的益生菌菌株对湿疹治疗可能还是有一定的作用。