文献简介

出版社:Pediatr Allergy Immunol

作  者:Aida Semic-Jusufagic*, Philippe Gevaert*, Claus Bachert, Clare Murray, Angela Simpson and Adnan Custovic

编  号:10.1111/j.1399-3038.2010.01077.x

关键字:

年  份:2010   点击量:725

文献摘要

    Eosinophils are involved in the pathogenesis of allergic disease, and increasing blood and tissue eosinophilia is related to the presence and severity of symptoms (1, 2). Eosinophil precursors in the bone marrow are differentiated and activated under the influence of several cytokines, mainly IL-3, IL-5 and GM-CSF. Eosinophil proliferation, homing and local survival in peripheral tissues depend on IL-5 stimulation.