文献简介

出版社:Australasian Journal of Dermatology

作  者:Frederick J Lee,Brad S Frankum and Constance H Katelaris

编  号:10.1111/j.1440-0960.2011.00789.x

关键字:

年  份:2012   点击量:952

文献摘要

Abstract.

摘要:

We report a small, but novel case series of four adults with severe generalized atopic eczema (AE) not responsive to several other immunomodulatory therapies, who were treated with oral tacrolimus(5 mg twice-daily). Three of the four patients failed therapy with systemic tacrolimus, despite two of these showing an initial clinical response; the fourth patient remains on tacrolimus monotherapy with good control of skin disease. Although oral tacrolimus was well-tolerated in this small group of adults, the clinical efficacy in this series for severe AE was poor. Tacrolimus may yet have a role in less severe disease, but larger prospective studies are required to qualify its place as a treatment option in AE.

    我们报告了4例常见但却很有特点的病例系列,他们都接受了口服他克莫司的治疗(5mg 2/日)。这些成年患者有严重的全身过敏性湿疹(AE) ,对其他免疫调节疗法无效。尽管两名患者表现出了初始的临床反应,但是其中的三名全身应用他克莫司治疗的患者显示治疗失败;第四位患者仍使用他克莫司单一治疗,皮肤疾病得到了良好地控制。尽管在这个成人小组中口服他克莫司表现出了良好的耐受性,但对于严重的AE患者,临床疗效较差。他克莫司可能在症状较轻的疾病上启作用,但还需要大量的前瞻性研究来证实它可以作为一种治疗AE的方法。