文献简介

出版社:Australasian Journal of Dermatology

作  者:Hugh Roberts and David Orchard

编  号:10.1111/j.1440-0960.2010.00634.x

关键字:Methotrexate, paediatric, discoid,eczema.

年  份:2010   点击量:987

文献摘要

We present a case series of 25 paediatric patients with refractory discoid eczema treated with methotrexate. Patients were commenced on either 5 mg or 10 mg of methotrexate per week. Sixteen patients (64%) completely cleared their eczema after an average of 10.5 months of methotrexate therapy. A further three patients (12%) have responded well and are almost clear at the time of writing. Methotrexate was well tolerated by the majority of patients and no serious adverse events were observed. Methotrexate should be considered in moderate to severe paediatric discoid eczema that has failed to respond to conventional therapies.

我们报道了用甲氨蝶呤治疗患有顽固性钱币状湿疹的25位儿科患者的病例系列。患者每周开始服用5毫克或10毫克的甲氨蝶呤。在甲氨蝶呤治疗平均10.5个月后,16(64%)患者的湿疹被完全清除。另有3(12%)患者反应良好,并且在撰写本文时几乎痊愈。大部分患者对于甲氨蝶呤的耐受性良好且无严重的副反应。甲氨蝶呤应被考虑运用到对于常规疗法无效的中度到重度的儿科钱币状湿疹。