文献简介

出版社:Journal of the European Academy of Dermatology and Venereology

作  者:N. Kac¸ ar, L. Tas¸ lı , S. Korkmaz, S¸ Ergin, B.S¸ . Erdog an

编  号:10.1111/j.1468-3083.2011.04186.x

关键字:Plantar warts,either cryotherapy, topical CPS

年  份:2011   点击量:1280

文献摘要

    Background.Plantar warts are refractory to any form of treatment. High cure rates have been reported with a topical proprietary formulation consisting of 1% cantharidin, 5% podophyllotoxin and 30% salicylic acid (CPS). However, no data exists comparing the efficacy of this formulation with another treatment. Cryotherapy is a method that is also widely used in the treatment of plantar warts. Likewise, there is no evidence that it is more effective than any topical treatment.

研究背景:

采用任何形式的治疗都难以治愈跖疣。已有报道称采用一种含1%斑蝥素、5%足叶草毒素和30%的水杨酸(CPS)的外用专有制剂可以获得高治愈率。但是,目前还没有比较这种制剂与其他治疗方法疗效的的数据。冷冻疗法也是一种被广泛用于治疗跖疣的方法。同样,没有证据表明它比任何局部治疗更有效。

Objective

We aim to compare the efficacy of topical CPS and cryotherapy in the treatment of plantar warts.

研究目的:

我们的目地是比较外用CPS和冷冻疗法治疗跖疣的疗效。

 Methods

Patients with plantar warts were consecutively treated with either cryotherapy or topical CPS. Both treatments were performed every 2 weeks for up to five sessions. In patients without complete clearance, the therapy was switched to the other treatment option.

研究方法:

跖疣患者采用冷冻疗法或外用CPS连续治疗。这两种治疗方法均持续五个疗程,每2周为1个疗程。在没有完全清除的患者身上,原先的疗法又被切换到其他治疗方法。

 Results

Twenty-six patients with a total of 134 warts were included. Fourteen patients were completely cleared of their warts with topical CPS, whereas only in five of 12 patients (41.7%) warts were completely cleared with cryotherapy (P = 0.001). In seven patients without complete clearance, the therapy was switched to CPS. Four of these patients missed the follow-up. While the two of the remaining three patients were cleared of their warts, one patient’s warts still failed to clear.

研究结果:

26位患者(共含134个疣)被纳入本项研究。采用CPS局部治疗的14例患者身上的疣被彻底清除,而采用冷冻治疗法的十二例患者中只有五例患者身上的疣(41.7%)被完全清除(P = 0.001)。7例未完全清除的患者,其治疗方法被切换到CPS。其中四位患者错过随访。而剩下三位患者中两位身上的疣被清除,另一位患者的疣仍未能清除。

Conclusion

Topical CPS is more effective than cryotherapy in the treatment of plantar warts.

研究总结:

对于跖疣的治疗,外用CPS比冷冻疗法更有效。