文献简介

出版社:Journal of Dermatological Treatment

作  者:JUNG EUN KIM, SUN JI KIM, JONG IK HWANG, KYUNGJIN LEE, HYUNJEONG PARK & BAIK KEE CHO

编  号:10.3109/09546634.2010.551534

关键字:intralesional injection, viral warts, 5-aminolevulinic acid, photodynamic therapy

年  份:2012   点击量:1017

文献摘要

Background: Although photodynamic therapy (PDT) using intralesional injection (ILI) can theoretically enhance the efficacy of the PDT, the effect of ILI-PDT on warts has not been reported in the literature so far.

研究背景:尽管,应用瘤内注射(ILI)光动力疗法(PDT)理论上可以提高PDT的疗效,但是至今尚未有ILI-PDT对尖锐湿疣影响的文献报道。

 

Methods:Eight patients with multiple viral warts were enrolled in the study. PDT was performed after the incubation for 1 h, followed by the ILI of aminolevulinic acid (ALA) into the warts. The treatment was repeated at 2–3 week intervals.

研究方法:八名多病毒疣患者纳入本次研究。1小时的潜伏期后进行PDT疗法随后在疣的瘤内注射(ILI)氨基乙酰丙酸(ALA)。每隔2 - 3周重复一次治疗。

 

Results: Fifty percent of patients showed good to cure response. Complete remission was observed in two patients. There was no apparent correlation between the initial severity of warts and the likelihood of response. No one reported severe adverse reaction.

研究结果:百分之五十的患者表现出良好的治疗反馈。在两名患者中观察到症状完全缓解。疣的初始严重程度与其反应可能性之间没有明显的相关性。没有报告显示有严重的不良反应。

 

Conclusions: The present study suggests that intralesional administration of ALA might be a safe and effective treatment option of thick treatment-resistant warts and can be performed with a shorter incubation period.

研究总结:目前的研究表明,瘤内注射ALA可能是对较厚的难治性尖锐湿疣的一种安全,有效的治疗选择,并且它可以在更短的潜伏期内进行治疗。