文献简介

出版社:Journal of Dermatological Treatment.

作  者:THIERRY SIMONART & VIVIANE DE MAERTELAER

编  号:10.3109/09546634.2010.500324

关键字:cimetidine, randomized clinical trial, wart, zinc

年  份:2012   点击量:872

文献摘要

Background: Systemic therapies are routinely used for the management of cutaneous warts. However, there is a lack of evidence-based data on their effectiveness.

研究背景:

系统性疗法常用来治疗皮肤疣。但是,它们的疗效缺乏以数据为基础的证据。

 

Objective:To assess the evidence for the efficacy of systemic treatments for cutaneous warts.

研究目的:

本文旨在评估系统性疗法治疗皮肤疣有效性的证据。

 

Methods: We designed a systematic review of the randomized controlled clinical trials (1962 to April 2010) investigating systemic therapies for the treatment of cutaneous warts. We obtained data from MEDLINE, PubMed, Current Contents, reference lists, and specialist textbooks, with no restriction on language. The main outcome measures were the total clearance of warts and the adverse effects.

研究方法:

我们设计了一项随机的、临床对照的、系统性回顾试验(从1962年至2010年4月),研究系统性疗法治疗皮肤疣的疗效。我们从MEDLINE、PubMed、 Current Contents、,参考文献目录和专业教科书中获得数据,且对语言没有限制。主要的测量结果是疣的总清除率及不良反应。

 

Results: There was substantial heterogeneity in the design of the trials. No consistent evidence was found for the efficacy of cimetidine, levamisole or homeopathy, and only limited evidence was found for the efficacy of zinc.

研究结果:

试验的设计存在大量的异质性。没有统一的证据表明西米替丁,左旋咪唑或顺势疗法的有效性,并且仅有有限的证据表明锌的有效性。

 

Conclusions: Reviewed trials of systemic treatments for cutaneous warts were highly variable in methods and quality, and there was a paucity of evidence from randomized, placebo-controlled trials on which to base the rational use of such therapies. Limited evidence is emerging that zinc may be effective in selected populations with zinc deficiency.

结论:

对于系统性治疗皮肤疣的回顾性实验在方法和质量上变化很大,并且缺乏合理使用这种疗法的随机、安慰剂对照试验的证据。有限的证据表明锌可能对于锌缺乏症的人群是有效的。