文献简介

出版社:British Journal of Dermatology

作  者:E. Hagforsen, H. Hedstrand, F. Nyberg

编  号:10.1111/j.1365-2133.2010.09819.x

关键字:Novel findings | Langerhans cells | interleukin-17 | expression

年  份:2010   点击量:637

文献摘要

Backgound Palmoplantar pustulosis (PPP) is a chronic and intensely inflammatory skin disease with pustules, erythema and scaling localized to the palms and soles. To date, no specific treatment is known. Earlier findings indicate the acrosyringium as the target for the inflammation.

研究背景:掌跖脓疱病是一种慢性、剧烈的炎症性皮肤病,伴有手掌和脚掌局部出现脓疱、红斑和鳞屑。迄今为止,还没有特别的治疗方法。早期的研究结果指出,顶端汗管是炎症的靶点。

Objectives To identify specific features of the PPP inflammatory cell infiltrate and mediators of inflammation, which might provide insight into the pathogenesis and possible future treatment of the disease.

研究目的:旨在识别掌跖脓疱病炎症细胞浸润和炎症介质的特定功能,这可能有助于我们深入了解该疾病的发病机制及其未来可能的治疗方法。

Methods Skin biopsies were taken from 23 patients with typical PPP (23 from involved skin and seven from noninvolved skin) and from 18 healthy controls (10 nonsmokers, eight smokers). Cell infiltrates and inflammation mediators were studied with immunohistochemistry.

研究方法:对23例典型掌跖脓疱病患者(23处受累皮损和7处非受累皮肤)以及18名健康对照个体(10名不抽烟者,8名抽烟者)的皮肤活组织样本进行检查。采用免疫组织化学学对细胞浸润和炎症介质进行研究。

Results A strong inflammation was observed in lesional skin of PPP. Our main findings of Langerhans cells and interleukin-17 close to or in the acrosyringium differs from findings in psoriasis vulgaris. Other inflammatory cells such as CD4+, CD8+, regulatory T cells and CD11a+ cells were also accumulated close to the sweat duct in epidermis and papillary dermis. More CD4+, CD8+, Langer-hans cells, plasmacytoid dendritic cells and a higher proportion of regulatory T cells ⁄CD3+ cells were seen in noninvolved palmar skin from patients with PPP compared with healthy controls.

研究结果:在掌跖脓疱病的皮损处观察到一个强烈的炎症症状。我们主要发现在顶体细胞中或附近有朗格汉斯细胞和白细胞介素17,这与寻常型银屑病中的研究结果不同。其它炎症细胞如CD4+CD8+、调节性T细胞和CD11a+细胞也积累在表皮和乳头真皮层的汗管附近。与健康对照个体相比,在掌跖脓疱病患者的非受累手掌皮肤处可以观察到更多的CD4 +CD8 +、朗格汉斯细胞、浆细胞样树突状细胞,调节性T细胞/ CD3+细胞的比例也较高。 

Conclusions Our novel findings indicate that the inflammation in PPP is initiated by the ‘stand-by’ innate immune system at the acrosyringium

研究结果:我们新的研究结果表明,掌跖脓疱病的炎症是由顶端汗管处的“待命”先天免疫系统发起的