文献简介

出版社:John Wiley & Sons A/S

作  者:Takuya Furuhashi, Kan Torii, Hiroshi Kato

编  号:

关键字:excimer light | open-label study | palmoplantar pustulosis | regulatory T cells | Th17 cells

年  份:2011   点击量:875

文献摘要

In this open-label study, we investigated the efficacy of excimer light (308 nm) with a filter to cut off wavelengths below 297 nm for the treatment of palmoplantar pustulosis (PPP). Twenty patients with PPP were recruited and treated once a week for a total of 30 sessions. Patient response was assessed every 10 sessions based on the Palmoplantar Pustulosis Area and Severity Index (PPPASI) score. Levels of Th17 cells and regulatory T cells (Treg) in the peripheral blood in patients with PPP were also evaluated. Mean PPPASI score was 19.5 at baseline, 13.2 at 10 treatments, 10.9 at 20 treatments and 9.5 at 30 treatments. Th17 levels after excimer therapy were not significantly different from those at baseline. In contrast, Treg levels after excimer therapy were significantly higher than those at baseline.

在这个开放性的研究中,我们探讨使用准分子光(308纳米)(带有过滤器以截止低于297纳米的波长)治疗掌跖脓疱病的疗效。20例掌跖脓疱病患者被纳入本项研究,患者每周治疗一次,共30次。每10次治疗后根据掌跖脓疱病的面积和严重程度指数值(PPPASI)对患者的反应进行评估。同时对掌跖脓疱病患者外周血中的Th17 细胞水平和调节T细胞(Treg)水平进行评估。掌跖脓疱病的面积和严重程度指数(PPPASI)值治疗前为19.5、10次治疗后为13.2、20次治疗后为10.9,30次治疗后为9.5 。准分子治疗后Th17细胞水平与治疗前相比没有显著区别。相比之下,在准分子治疗后Treg水平与治疗之前相比有显著增高。