文献简介

出版社:Actas Dermosifiliogr

作  者:E. Jorquera-Barquero,a,∗ M.C. Súarez-Marrero,a F. Fernández Girón,b J.J. Borrero Martínc

编  号:

关键字:Oxalosis; Livedo reticularis; Vasculopathy

年  份:2013   点击量:855

文献摘要

Oxalosis is a disease caused by the deposition of calcium oxalate in extrarenal tissues, most commonly bone, myocardium, retina, blood vessels, and skin, causing the clinical manifestations of the disease.Involvement of the blood vessels of the skin can give rise to livedo reticularis, acrocyanosis, ulcers, and gangrene.We present the case of a 60-year old woman with a history of recurrent renal lithiasis that had led to terminal renal failure requiring hemodialysis and, subsequently, peritoneal dialysis. The patient developed tender red-violaceous skin discoloration of sudden onset, consistent with livedo reticularis; the lesions progressed to form ulcers. Skin biopsy revealed oxalate vasculopathy. In this article we describe the characteristics of this rare disorder, its differentiation from calciphylaxis, and the therapeutic options.

草酸过多症是由草酸钙在肾外组织中的沉积而引起的一种疾病,引起该疾病的临床表现最常见于骨,心肌,视网膜,血管和皮肤的病变。皮肤的血管受累可能增加患有网状青斑、手足发绀、溃疡和坏疽的风险。我们报道了一例60岁的伴有复发性肾结石并导致终端肾功能衰竭的女性患者的病例,患者需要进行血液透析和腹膜透析进行治疗。患者突然发作,出现嫩红色紫罗兰色的皮肤色变,与网状青斑一致,皮肤病变加重形成溃疡。皮肤活检显示草酸血管病变。在这篇文章中,我们描述了这种罕见疾病的临床特点,与血管钙化的不同以及治疗方案的选择。