文献简介

出版社:J Thromb Thrombolysis

作  者:Jihane Abou Rahal • Rim S. Ishak • Zaher K. Otrock • Abdul-Ghani Kibbi • Ali T. Taher

编  号:10.1007/s11239-012-0743-5

关键字:Livedoid vasculopathy  Hypercoagulable state  MTHFR  Lupus anticoagulant  Low-molecular-weight heparin  Treatment

年  份:2012   点击量:931

文献摘要

Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. For many years, livedoid vasculopathy has been considered to be a primary vasculitic process.However, there has been evidence considering livedoid vasculopathy as an occlusive vasculopathy due to a hypercoagulable state. We present the case of livedoid vasculopathy in a 21-year-old female who had been suffering of painful lower extremity lesions of 3 years duration. The patient was found to be lupus anticoagulant positive and homozygous for methylenetetrahydrofolate reductase C677T mutation. The patient was successfully treated with low-molecular-weight heparin.

青斑血管病变以四肢部位疼痛性紫癜性皮损病变,经常伴有溃疡以及萎缩性愈合疤痕为特征。多年来,青斑血管病变被认为是血管炎性的主要过程。。然而,已有证据认为青斑血管病是血液高凝状态下的一种闭塞性血管病变。我们报道了一例21岁患有青斑血管病变的女性患者病例,该患者经历了为期3年的下肢痛苦性皮损病变。在患者体内发现有红斑狼疮抗凝物呈阳性和纯合的亚甲基四氢叶酸还原酶C677T发生突变。采用低分子量肝素进行治疗,患者被成功治愈。