文献简介

出版社:Wiley Periodicals

作  者:SUNG BIN CHO, MD,HEE JUNG KIM, MD,SEONGMIN NOH, MD

编  号:10.1111/j.1524-4725.2011.01915.x

关键字:an Ablative 10,600-nm Carbon Dioxide Fractional Laser | treatment | a prospective analysis

年  份:2011   点击量:876

文献摘要

BACKGROUND Treatment of syringoma aims to destroy the dermal tumor using methods that can include surgical excision,electrodessication, cryosurgery, chemical peeling, and laser ablation, but complete removal of syringomas is often unsuccessful, and recurrence occurs frequently.

背景 治疗汗管瘤的目的是为了破坏真皮肿瘤,可采用的方法包括手术切除、电子脱水、冷冻手术、化学剥脱术以及激光消融术,但通常无法成功去除汗管瘤,并且易反复发作。

OBJECTIVE To investigate the therapeutic efficacy of an ablative 10,600-nm carbon dioxide fractional laser system (CO2 FS) for the treatment of periorbital syringomas.

目的 旨在调查烧灼性10600 nm二氧化碳点阵激光系统(CO2 FS)治疗眶周汗管瘤的治疗效果。

METHODS Thirty-five patients with periorbital syringomas were treated with two sessions of CO2 FS at 1-month intervals. Laser fluences were delivered in two or three passes over the lower eyelids, using a pulse energy of 100 mJ and a density of 100 spots/cm2. Clinical improvement was assessed by comparing pre- and post-treatment clinical photographs and patient satisfaction rates. We examined the histological features of human periorbital syringomas treated with CO2 FS.

方法 35眶周汗管瘤患者均每隔一个月采用CO2 FS治疗两次。激光能量密度在二或三次内通过采用100 mJ的脉冲能量和100 spots/cm2的密度被传送入下眼睑中。临床症状的改善通过比较治疗前和治疗后的临床照片以及患者满意率进行评估。我们调查了采用CO2 FS治疗的眶周汗管瘤患者的组织学特征。

RESULTS Evaluation of clinical results 2 months after treatment showed that 15 of the 35 patients (42.9%) demonstrated marked (51-75%) clinical improvement, 12 (34.3%) had moderate (26-50%) clinical improvement, five (14.3%) showed minimal (0-25%) improvement, and three (8.6%) showed near total (≥75%) improvement. Clinical improvement scores were less 4 months after the second CO2 FS treatment (not statistically significant). The mean maximal depth of the necrotic column was 1,236.3 mm. A specimen obtained from the infraorbital area immediately after treatment showed formation of necrotic columns on the interfollicular skin.

结果对治疗后2个月的临床效果进行评估,我们发现35例患者中有15例(42%)临床症状有明显改善(51-75%),12例(51-75%)临床症状有中等改善(26-50%),只有五例(14.3%)表现出极小的改善(0-25%),以及三例(8.6%)几乎完全改善(≥75%)。在第二次CO2 FS治疗四个月后(无统计学显著性差异)临床症状改善较少。坏死柱的平均最大深度为1,236.3mm。治疗后立即从眼眶下区域获得的样本显示在滤泡间皮肤上形成了坏死柱。

CONCLUSION The use of CO2 FS can have a positive therapeutic effect on periorbital syringomas.

结论 CO2 FS对眶周汗管瘤具有积极的治疗效果。