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Werner综合征4330T>C( Cys1367Arg )基因变异不影响体外拓扑异构酶抑制剂和铂类化合物的细胞毒性2014.03.21
The Werner’s syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds
目的 Werner’s syndrome (WS)is a recessive disorder of premature onset of processes associated with aging. DefectiveDNA repair has been reported after exposure of cells isolated from WS patientsto DNA-damaging agents. The germline 4330T>C (Cys1367Ar...
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