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Breast cancer occurred after Hodgkin’s disease: Clinico-pathological features, treatments and outcome: Analysis of 214 cases2014.03.07
Abstract:Background: Secondary tumours (ST) represent a major concern in survivors of Hodgkin’s disease (HD). Breast cancer (BC) is the most frequent ST among young treated women.Material and methods: One hundred and eighty-nine women treated for H...
Plasmacytoid Dendritic Cell And Cd4+ T Cell Defi ciencies In Untreated Hodgkin’s Disease: Implications For Susceptibility To Opportunistic Infections2014.03.07
Abstract:Hodgkin’s Disease (HD), usually a malignancy of early B-cells, is associated with an increased risk of opportunistic infections (OI). Previous studies of infectious complications of HD have documented skin anergy and a variety of in vitro ...
Clonally identical Hodgkin’s disease develops after allogeneic hematopoietic cell transplant for CLL2014.03.07
Abstract:We present a patient with CLL who achieved remission following allogeneic BMT and donor lymphocyte infusion, but 1.5 years later developed clonally identical Hodgkin’s disease.
Breast Cancer in Young Women After Treatment for Hodgkin’s Disease During Childhood or Adolescence2014.03.07
Background: The treatment of Hodgkin’s disease (HD; also called Hodgkin’s lymphoma) in children and adolescents with radiotherapy and chemotherapy leads to high survival rates but has a number of late effects. The most serious one is the developmen...
c-JUN N-terminal kinase (JNK) is activated and contributes to tumor cell proliferation in classical Hodgkin lymphoma2014.03.07
经典型霍奇金淋巴瘤中c- JUN氨基末端激酶(JNK)激活并促进肿瘤细胞增殖
c-JUN氨基末端激酶(JNK)通过上游MAPK激酶(MKK)激活/磷酸化,并且反过来,使它的主要底物c- JUN,激活蛋白-1(AP-1)转录因子的成员之一磷酸化和激活。c- JUN在经典型霍奇金淋巴瘤(cHL)的霍奇金和里德-斯腾伯格细胞(HRS)中过表达与被激活,但其激活机制尚不清楚。...
Laparoscopic splenectomy complicated by pancreatic cyst in the course of Hodgkin’s disease: case report2014.03.07
Abstract:This paper describes a case of a patient suffering from Hodgkin’s disease and treated by means of minimally invasive surgery: laparoscopic splenectomy. The performance of laparoscopic splenectomy led to a complication in the form of a pancr...
Hodgkin’s disease of the thoracic vertebrae2014.03.07
BACKGROUND CONTEXT: Hodgkin’s disease rarely occurs in the spine, which is usually a setting for the advanced form of the disease. PURPOSE: To describe an unusual case of isolated, primary spinal Hodgkin’s disease and to draw attention to this dise...
Primary Hodgkin’s disease of the thymus2014.03.07
Abstract:The thymus is a lymphoid organ located in the antero-superior mediastinum and composed of heterogeneous admixture of lymphoid and epithelial elements. Thymic tumors are dominated by thymoma; lymhomas are uncommon involving the gland seconda...
Spontaneous regression of primary progressive Hodgkin’s lymphoma in a pediatric patient: A case report and review of literature2014.03.07
Abstract:Spontaneous regression of malignancies is a very rare phenomenon. Our research of existing literature yielded only 16 cases of Hodgkin’s lymphoma which regressed spontaneously. The outcome of primary progressive Hodgkin’s lymphoma is poor...
Isolated, Primary Spinal Epidural Hodgkin’s Disease in a Child2014.03.07
一名单独的、主要发生在脊髓硬膜外的霍奇金病患儿
一名12岁的男孩表现为腰酸及双侧下肢渐进性无力。放射学检查发现其在硬膜外腔有一个L1-L3级的团块。患者进行了椎板切除和后路减压。组织病理学检查发现为淋巴细胞优势型霍奇金病。所有其他调查(包括胸部和腹部电脑断层扫描、骨扫描、镓扫描、骨髓穿刺和脑脊液研究)均...
New drugs and targeted treatments in Hodgkin’s lymphoma2014.03.06
霍奇金淋巴瘤中的新药和靶向治疗
最近几年我们正在开发的新的药物有可能改变复发性和难治性霍奇金淋巴瘤患者的治疗方法。贝伦妥单抗-维多汀的治疗已被FDA批准,并且其他药物也有希望,如组蛋白去乙酰化酶抑制剂、苯达莫司汀、来那度胺和m-TOR抑制剂。
Immunologic pathomechanism of Hodgkin’s lymphoma2014.03.06
霍奇金淋巴瘤的免疫病理机制
霍奇金淋巴瘤是一种免疫系统的淋巴恶性肿瘤。霍奇金和里德-斯腾伯格细胞(HRS)的特异性病征主要来自单克隆的、前凋亡B细胞,以及他们的重排,体细胞突变的免疫球蛋白重链。在一个合适的微环境中,HRS细胞通过几种机制逃避凋亡,包括单基因突变和异常的信号通路。最终,...
Hodgkin’s lymphoma in adults2014.03.05
Abtsract:Management of Hodgkin’s lymphoma continues to develop. Outcomes for patients with favourable-risk, early-stage disease are excellent, and serial reductions in intensity of treatment have been made to retain the excellent prognosis while re...
QUALITY OF RADIOTHERAPY REPORTING IN RANDOMIZED CONTROLLED TRIALS OF HODGKIN’S LYMPHOMA AND NON-HODGKIN’S LYMPHOMA: A SYSTEMATIC REVIEW2014.03.05
Purpose: Standards for the reporting of radiotherapy details in randomized controlled trials (RCTs) are lacking. Although radiotherapy (RT) is an important component of curative therapy for Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL), ...
Circulating tumor cells in Hodgkin’s lymphoma—A review of the spread of HL tumor cells or their putative precursors by lymphatic and hematogenous means, and their prognostic significance2014.03.05
AbstractAbout 15% of patients diagnosed with classical Hodgkin’s lymphoma (cHL) are considered high risk with unfavorable prognosis. The biology of the disease bears a direct relationship to its clinical course. However, some aspects of the disease ...
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