文献资料 > 冷球蛋白血症
Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame?2015.01.15
Mixed cryoglobulinemia (MC) is theextrahepatic manifestation most strictly correlated with hepatitis C virus (HCV)infection; it is a benign autoimmune and lymphoproliferative disorder thatevolves to lymphoma in 5%-10% of cases. MC is reputed to be a ...
Hepatitis C virus–induced cryoglobulinemia2015.01.15
In this review we discuss the clinical manifestations, pathogenesis, andtreatment of hepatitis C virus(HCV)–related cryoglobulinemia. HCV is a majorcause of liverrelated morbidity and is increasingly recognized as an instigatorof B-cell lymphoprolif...
HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type IIMixed Cryoglobulinemia: A Concurrent Pathogenetic Role2015.01.15
The association between hepatitis C virus (HCV) infection and type IImixed cryoglobulinemia (MCII) is well established, but the role played bydistinct HCV proteins and by specific components of the anti-HCV humoral immuneresponse remains to be clearl...
Cryoglobulinemic Disease2015.01.15
“Cryoglobulinemia”refersto the presence of cryoglobulins(immunoglobulins that precipitate at variabletemperatures < 37°C ) in serum. Monoclonal cryoglobulinemia (type I) involves a single type ofmonoclonal immunoglobulin, while mixed cryogl...
Hepatitis C Virus Infection and Mixed Cryoglobulinemia2015.01.15
丙型肝炎病毒感染和混合性冷球蛋白血症
丙型肝炎病毒(HCV)慢性感染被认为是引发混合性冷球蛋白血症(MC)的主要原因。其可以持久连续刺激宿主免疫系统,并产生循环免疫复合物(ICs),其中三分之一伴有冷沉淀物性质。一些因素可能会引发ICs的生物活性,但其中大部分因素尚未知晓。其中,补体因子在冷不溶性I...
Cryofiltration in the Treatment of Cryoglobulinemia and HLA Antibody-Incompatible Transplantation2015.01.15
Cryofiltration is a technique in which plasma is separated from blood andchilled, leading to the formation of “cryogel”, a composite of heparin,fibronectin, fibrinogen, immunoglobulins, and other proteins. This is retained byfurther filtration and ...
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21low cells overexpressing Stra132015.01.15
A clonal population of B cells expressing a VH1-69-encoded idiotypeaccumulates in hepatitis C virus (HCV) associated mixed cryoglobulinemia (MC).These cells arephenotypically heterogeneous, resembling either typical marginalzone (MZ) B cells(IgM+IgD+...
Interferon mono-therapy for symptomatic HCV-associated mixed cryoglobulinemia: meta-analysis of clinical studies2015.01.15
Objective :Mixed cryoglobulinemia (MC) is an importantcomplication of hepatitis C virus (HCV) infection. Antiviral therapy is now animportant approach for symptomatic HCV-MC ; some information exists on IFN mono-therapyfor symptomatic HCVMC in the no...
Antiviral Therapy of Symptomatic HCV-Associated Mixed Cryoglobulinemia: Meta-Analysis of Clinical Studies2015.01.15
Hepatitis C virus (HCV) infection may be associated withextra-hepatic illness including mixed cryoglobulinemia. Evidence on HCV-relatedmixed cryoglobulinemia in the non-transplantation setting exists even if itsappropriate management remains unclear....
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers2015.01.15
巴西丙型肝炎病毒携带者中抗平滑肌抗体和冷球蛋白血症与晚期肝纤维化相关
冷球蛋白血症和非器官特异性抗体是由丙型肝炎病毒(HCV)引发的慢性感染的自体免疫生物标志物。本文报道了在HCV携带者中抗平滑肌抗体(SMA)和冷球蛋白血症的存在与慢性肝病之间的关联。本研究纳入了65例未经治疗的HCV患者,其中38名女性和27名男性。通过冷冻沉淀对冷球...
Somatic Hypermutations Confer Rheumatoid Factor Activity in Hepatitis C Virus–Associated Mixed Cryoglobulinemia2015.01.15
Objective Hepatitis C virus (HCV) is the most frequent causeof mixed cryoglobulinemia (MC), which is characterized by endothelialdeposition of rheumatoid factor (RF)–containing immune complexes and end-organvasculitis. MC is a lymphoproliferative di...
Role of MicroRNA Profile Modifications in Hepatitis C Virus-Related Mixed Cryoglobulinemia2015.01.15
HepatitisC virus infection is closely related to lymphoproliferative disorders (LPDs),including mixed cryoglobulinemia (MC) and some lymphomas. Modification of theexpression of specific microRNAs (miRNAs) has been associated with different autoimmune...
Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL22015.01.15
The aim was to investigate circulating levels of interelukin(IL)-1β, IL-6 and tumor necrosis factor (TNF)-α,chemokine (C–X–C motif)ligand (CXCL)10, CXCL11 and chemokine (C–C motif) ligand (CCL)2 in “mixedcryoglobulinemia and hepatitis C” (MC+H...
B Cell Homeostasis in Chronic Hepatitis C Virus–Related Mixed Cryoglobulinemia Is Maintained Through Naȉve B Cell Apoptosis2015.01.15
Mixed cryoglobulinemia (MC) is the most commonextrahepatic manifestation of chronic hepatitis C virus (HCV) infection.Although the formation of inflammation-triggering immune complexes is driven byclonal expansions of autoreactive B cells, we found t...
Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia2015.01.15
慢性丙型肝炎中的炎症生物标志物:与肝组织病理学、HCV基因型和冷球蛋白血症相关
目的 本文调查研究了慢性丙型肝炎患者体内炎症生物标志物的分布,以及与肝纤维化、肝脏炎性组织活性、病毒基因型和冷球蛋白血症的相关性。Subjects and methods Seventy-eightuntreated patients were studied. Biomarker levels weredetermined by immunoassays, cry...
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