Eczema therapeutics in children: what do the clinical trials say?2015.09.08
儿童湿疹的治疗:临床试验得出什么结论?
Eczemaor atopicdermatitis is a common childhood atopic disease associated withchronicity and impaired quality of life. As there is no cure for the disease,treatment relies on topical and systemic anti-allergic or immunomodulating therapies.Topical co...
Poor efficacy of oral tacrolimus in the treatment of severe generalized atopic eczema in adults: A small retrospective case2013.11.13
口服他克莫司治疗成人严重的全身过敏性湿疹疗效不佳:一则简短的回顾性病例
We report a small, but novel case series of four adults with severe generalized atopic eczema (AE) not responsive to several other immunomodulatory therapies, who were treated with oral tacrolimus(5 mg twice-daily). Three of the four patients failed...
Elevated Peripheral Allergen-Specific T Cell Response Is Crucial for a Positive Atopy Patch Test Reaction2013.11.06
外周过敏原特异性T细胞应答增强对阳性APT反应至关重要
过敏性湿疹是一种慢性炎症性皮肤病,它是几种能被鉴别的疾病亚群中的其中之一。斑贴试验(APT)揭示了过敏原致敏作用在过敏性湿疹患者体内也缺乏可检测的过敏原特异性IgE,提出在反应中除IgE之外的重要因素。这里我们研究APT反应和过敏原特异性外周IgE以及T细胞反应在过敏...
Methotrexate is a safe and effective treatment for paediatric discoid (nummular) eczema: A case series of 25 childrena2013.11.06
甲氨蝶呤-一种安全有效的儿科圆盘状(钱币状)湿疹疗法:一个25位儿童患者的病例系列
我们报道了用甲氨蝶呤治疗患有顽固性钱币状湿疹的25位儿科患者的病例系列。患者每周开始服用5毫克或10毫克的甲氨蝶呤。在甲氨蝶呤治疗平均10.5个月后,16位(64%)患者的湿疹被完全清除。另有3位(12%)患者反应良好,并且在撰写本文时几乎痊愈。大部分患者对于甲氨蝶呤的耐...
Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials2013.11.05
Background. Long-term low-level topical anti-inflammatory therapy has been suggested as a new paradigm in the treatment of atopic eczema (AE).
Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review2013.11.05
Background. An association between the bacterium Staphylococcus aureus and atopic eczema has been recognized for many years. Although few would dispute the benefit of systemic antibiotics in people with overtly clinically infected eczema,the clin...
Is there a rural⁄urban gradient in the prevalence of eczema? A systematic review2013.11.05
Background. Eczema affects approximately 10% of all schoolchildren in the western world and has shown an increase over the past decades in ‘developing’ countries.Numerous factors have been suggested that might contribute to the increasingpreval...
Homeopathy for eczema: a systematic review of controlled clinical trials2013.11.05
Background. Homeopathy is often advocated for patients with eczema.Objectives This article systematically reviews the evidence from controlled clinical trials of any type of homeopathic treatment for any type of eczema.
Self-reported Lifetime Prevalence of Atopie Dermatitis and Comorbidity with Asthma and Eczema in Adulthood: A Population-based Cross-sectional Survey2013.11.05
Atopie dermatitis and its co-morbidity with asthma and allergy is well described in younger age groups. However, population-based studies on adults with atopie dermatitis in childhood are sparse.
Determinants of current hand eczema: results from case–control studies nested in the PACO follow-up study (PACO II)2013.11.05
Background. Hand eczema is often a result of the interplay of exogenous and endogenous risk factors. Epidemiological studies demonstrating the interrelationship between these factors are lacking.
The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: A population-based birth cohort study2013.11.05
Abstract. Although "atopic march" is a popular concept, the relationship between eczema and subsequent asthma is far from clear.However, some cohort studies have shown the possibility of two different allergic phenotypes in those who pre...
The effect of a corticosteroid cream and a barrier-strengthening moisturizer in hand eczema. A double-blind, randomized, prospective, parallel group clinical trial2013.11.05
Background. Hand eczema is a common and persistent disease with a relapsing course. Clinical data suggest thatonce daily treatment with corticosteroids is just as effective as twice daily treatment.
Laparo-endoscopic single-site (LESS) radical nephrectomy with renal vein thrombectomy: initial report2013.11.05
Background. By combining trocar sites and extraction incision, Laparo-endoscopic Single-site Surgery (LESS) may provide less morbidity than traditional laparoscopy. Concerns continue about LESS for locally advanced tumors. We present our experienc...
Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children2013.11.05
Eosinophils are involved in the pathogenesis of allergic disease, and increasing blood and tissue eosinophilia is related to the presence and severity of symptoms (1, 2). Eosinophil precursors in the bone marrow are differentiated and activated under...
Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study2013.11.05
Background. Eczema is a prevalent skin disease that is mainly characterized by systemic deviation of immune response and defective epidermal barrier. Th2 cytokines, such as IL-13 and transcription factor STAT6 are key elements in the inflammatory...
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