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文献 段落翻译:Reactivation of Herpes Simplex Virus [复制链接]

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Background

      The association between initiation of antiretroviraltherapy (ART) for human immunodeficiency virus (HIV) infection and possible herpessimplex virus type 2 (HSV-2) shedding and genital ulcer disease(GUD) has not been evaluated.

翻译:

背景:

    目前,人类免疫缺陷病毒(HIV)感染的抗逆转录病毒疗法(ART)开始和可能出现的单纯疱疹-2型病毒(HSV-2)脱落以及生殖器溃疡性疾病(GUD)之间的关系尚未得到评估。

校对:

背景:

    目前,人类免疫缺陷病毒(HIV)感染的抗逆转录病毒疗法(ART)开始和可能出现的单纯疱疹-2型病毒(HSV-2)脱落以及生殖器溃疡性疾病(GUD)之间的关系尚未得到评估。


Methods:

      GUD andvaginal HSV-2 shedding were evaluated among women coinfected with HIV and HSV-2(n = 440 for GUD and n = 96 for HSV-2 shedding) who began ART while enrolled in a placebo-controlled trial of HSV-2 suppression withacyclovir in Rakai, Uganda.
Monthlyvaginal swabs were tested for HSV-2 shedding, using a real-time quantitative polymerase chain reaction assay. Prevalence risk ratios (PRRs) of GUD wereestimated using log binomial regression.Randomeffects logistic regression was used to estimate odds ratios (ORs) of HSV-2 shedding.

翻译:

方法:

    在拉卡伊,乌干达,对HIV病毒和HSV-2双重感染的女性患者(n=440GUD患者和n=96 HSV-2脱落患者)的GUD和阴道HSV-2脱落进行评估。这些患者在加入采用阿昔洛韦抑制HSV-2的安慰剂对照试验时开始接受ART采用实时定量PCR法对每月阴道拭子标本中的HSV-2脱落进行检测。通过二项回归模型评估GUD的患病风险率(PRRs)HSV-2脱落比值比(ORs)采用随机效应logistic回归进行评估。

校对:

方法:

    在拉卡伊,乌干达,对HIV病毒和HSV-2双重感染的女性患者(n=440GUD患者和n=96 HSV-2脱落患者)的GUD和阴道HSV-2脱落进行评估。这些患者在加入采用阿昔洛韦抑制治疗HSV-2的安慰剂对照试验时开始接受ART采用实时定量PCR法对每月阴道拭子标本中的HSV-2脱落进行检测。通过二项回归模型评估GUD的患病风险率(PRRs)HSV-2脱落比值比(ORs)采用随机效应logistic回归进行评估。


Results:

      Compared with pre-ART values, GUD prevalence increased significantly within the first 3 months after ART initiation (adjusted PRR, 1.94;95% confidence interval [CI], 1.04–3.62) and returned to baselineafter 6 months of ART (adjusted PRR, 0.80; 95% CI, .35–1.80). Detection of HSV-2 shedding was highest in the first 3 months after ART initiation (adjusted OR, 2.58; 95%CI, 1.48–4.49). HSV-2 shedding was significantly less common among women receiving acyclovir(adjusted OR, 0.13; 95% CI, .04–.41).

翻译:

结果:

    与之前的ART值相比,ART开始后前3个月内GUD患病率显著增加(校正PRR1.9495%置信区间,1.04-3.62, ART治疗6个月后,返回到基线(校正PRR0.8095%置信区间,.35-1.80)。ART开始后前3个月,检测到HSV-2脱落率最高(校正OR2.5895%置信区间,1.48-4.49)。在接受阿昔洛韦治疗的女性患者中,HSV-2的脱落很少见(校正OR0.1395%置信区间,0.04 - 0.41)。

校对:

结果:

    与开始ART相比,ART开始后3个月内GUD患病率显著增加(校正PRR1.9495%置信区间,1.04-3.62, ART治疗6个月后,返回到基线(校正PRR0.8095%置信区间,.35-1.80)。ART开始后3个月,检测到HSV-2脱落率最高(校正OR2.5895%置信区间,1.48-4.49)。在接受阿昔洛韦治疗的女性患者中,HSV-2的脱落很少见(校正OR0.1395%置信区间,0.04 - 0.41)。


Conclusions:

      The prevalence of HSV-2 shedding and GUD increased significantly after ART initiation, possibly because of immune reconstitution inflammatory syndrome. Acyclovir significantly reduced bothGUD and HSV-2 shedding and should be considered to mitigate these effectsfollowing ART initiation.

翻译:

结论:

      ART开始后, HSV-2脱落和GUD的患病率显著增加,这可能是由于免疫重建炎症综合征的原因。阿昔洛韦能显著减少GUDHSV-2的脱落,应考虑减少ART开始后所伴随的这些影响。

校对:

结论:

      ART开始后, HSV-2脱落和GUD的患病率显著增加,这可能是由于免疫重建炎症综合征所致。阿昔洛韦能显著减少GUDHSV-2脱落,可以考虑用来治疗ART开始后所伴随的这些影响。


最后编辑zyy 最后编辑于 2013-12-27 12:22:38
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2#

看了,翻译天天进步一点点
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3#

最新的进展!
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4#

该用户帖子内容已被屏蔽
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5#

实用
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6#

好好学英语,有用!
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