黑色素瘤靶向治疗原理
题名: 黑色素瘤靶向治疗原理
摘要: Over the past decade, there has been significant advancement in the understanding of the pathophysiology of melanoma. These advancements have led to the systematic development of new effective therapies for advanced disease in the form of molecularly targeted therapy and immunotherapy. Randomized tr...

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天疱疮
关键词:天疱疮

天疱疮最新文献

Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, parane...2014.11.18
非经典型天疱疮:疱疹样天疱疮,IgA天疱疮,副肿瘤性天疱疮,IgG/IgA天疱疮
天疱疮是一组自身免疫性表皮内大疱性疾病,通常分为两种主要类型:寻常型天疱疮和落叶型天疱疮。疱疹样天疱疮、IgA天疱疮、副肿瘤性天疱疮和IgG/ IgA天疱疮是天疱疮中比较罕见的临床类型,临床、组织学和免疫病理学的部分特征与经典天疱疮类型有所不同。...
Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantib...2013.12.27
肽介导的桥粒芯糖蛋白3交联可以避免寻常型天疱疮自身抗体诱导的皮肤起疱
在寻常型天疱疮,一种危及生命的自身免疫性皮肤病中,由于自身抗体导致表皮水疱。这种自身抗体主要针对桥粒钙粘素桥粒芯糖蛋白3(DSG3)和DSG1,从而导致角质细胞丧失凝聚力。由于对疾病的发病机制了解有限,目前的治疗主要依赖于非特异性长期免疫抑...
Homologous regions of autoantibody heavy chain complementarity-determining regio...2013.12.27
Abstrcat: Pemphigus is a life-threatening autoimmune disease in which antibodies specific for desmogleins (Dsgs) cause loss of keratinocyte cell adhesion and blisters. In order to understand how antibodies cause pathogenicity a...
Cytokine gene polymorphisms in Tunisian endemic pemphigus foliaceus: A possible ...2013.12.27
Abstract: Polymorphism in the genes of TH2 cytokines and/or theirs receptors can influence serum cytokine levels in and the switch to the pathologic IgG4 auto-antibodies. In order to underline the role of these genes in the aeth...